Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

The development of HIV integrase (IN) strand transfer inhibitors (INSTIs) and our understanding of viral resistance to these molecules have been hampered by a paucity of available structural data. We recently reported cocrystal structures of the prototype foamy virus (PFV) intasome with raltegravir...

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Библиографические подробности
Главные авторы: Hare, Stephen, Vos, Ann M., Clayton, Reginald F., Thuring, Jan W., Cummings, Maxwell D., Cherepanov, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993412/
https://ncbi.nlm.nih.gov/pubmed/21030679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010246107
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