Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac effectively prevent colon cancer in humans and rodent models. However, their cellular targets and underlying mechanisms have remained elusive. We found that dietary sulindac induced apoptosis to remove the intestinal stem cells with nucl...

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Detalhes bibliográficos
Main Authors: Qiu, Wei, Wang, Xinwei, Leibowitz, Brian, Liu, Hongtao, Barker, Nick, Okada, Hitoshi, Oue, Naohide, Yasui, Wataru, Clevers, Hans, Schoen, Robert E., Yu, Jian, Zhang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993406/
https://ncbi.nlm.nih.gov/pubmed/21041628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010430107
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