Inflammatory arthritis in caspase-1 gene deficient mice: Contribution of proteinase 3 for caspase-1-independent production of bioactive IL-1β

OBJECTIVE: Caspase-1 is a known cysteine proteases and is a critical component of the inflammasome. Caspase-1 and neutrophil serine proteases, such as proteinase 3 (PR3) can process pro-IL-1β a crucial cytokine linked to the pathogenesis of rheumatoid arthritis, but their relative importance is unkn...

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Main Authors: Joosten, Leo A.B., Netea, Mihai G., Fantuzzi, Giamila, Koenders, Marije I., Helsen, Monique M.A., Sparrer, Helmut, Pham, Christine T., van der Meer, Jos W.M., Dinarello, Charles A., van den Berg, Wim B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993325/
https://ncbi.nlm.nih.gov/pubmed/19950280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.25006
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