Inflammatory arthritis in caspase-1 gene deficient mice: Contribution of proteinase 3 for caspase-1-independent production of bioactive IL-1β

OBJECTIVE: Caspase-1 is a known cysteine proteases and is a critical component of the inflammasome. Caspase-1 and neutrophil serine proteases, such as proteinase 3 (PR3) can process pro-IL-1β a crucial cytokine linked to the pathogenesis of rheumatoid arthritis, but their relative importance is unkn...

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書誌詳細
主要な著者: Joosten, Leo A.B., Netea, Mihai G., Fantuzzi, Giamila, Koenders, Marije I., Helsen, Monique M.A., Sparrer, Helmut, Pham, Christine T., van der Meer, Jos W.M., Dinarello, Charles A., van den Berg, Wim B.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993325/
https://ncbi.nlm.nih.gov/pubmed/19950280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.25006
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