Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G(αq) protein-induced cardiomyopathy

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy and progression to heart failure have been under intense invest...

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Hauptverfasser: Timofeyev, Valeriy, Porter, Cliff A., Tuteja, Dipika, Qiu, Hong, Li, Ning, Tang, Tong, Singapuri, Anil, Han, Pyung-Lim, Lopez, Javier E., Hammond, H. Kirk, Chiamvimonvat, Nipavan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993201/
https://ncbi.nlm.nih.gov/pubmed/20709863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01208.2009
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