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METABOLISM OF N-ALKYLATED SPERMINE ANALOGUES BY POLYAMINE AND SPERMINE OXIDASES

N-alkylated polyamine analogues have potential as anticancer and antiparasitic drugs. However, their metabolism in the host has remained incompletely defined thus potentially limiting their utility. Here, we have studied the degradation of three different spermine analogues N,N′-bis-(3-ethylaminopro...

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Autori principali: Häkkinen, Merja R., Hyvönen, Mervi T., Auriola, Seppo, Casero, Robert A., Vepsäläinen, Jouko, Khomutov, Alex R., Alhonen, Leena, Keinänen, Tuomo A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992990/
https://ncbi.nlm.nih.gov/pubmed/20012116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-009-0429-2
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