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α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by spermidine, spermine, and some of their analogs, and...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Hyvönen, Mervi T., Khomutov, Maxim, Vepsäläinen, Jouko, Khomutov, Alex R., Keinänen, Tuomo A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151227/
https://ncbi.nlm.nih.gov/pubmed/34068700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11050707
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