Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO), human spermine (Spm) oxidase (SMOX) and yeast polyamine oxidase (Fms1), we demonstrate that these fundamental properties of the enzymes may...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Keinänen, Tuomo A., Grigorenko, Nikolay, Khomutov, Alex R., Huang, Qingqiu, Uimari, Anne, Alhonen, Leena, Hyvönen, Mervi T., Vepsäläinen, Jouko
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131205/
https://ncbi.nlm.nih.gov/pubmed/30006473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180527
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