Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors

RNA splicing is required to remove introns from pre-mRNA and alternative splicing generates protein diversity. Topoisomerase I (Top1) has been shown to be coupled with splicing by regulating SR splicing proteins. Prior studies on isolated genes also showed that Top1 poisoning by camptothecin (CPT),...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Solier, Stéphanie, Barb, Jennifer, Zeeberg, Barry R., Varma, Sudhir, Ryan, Mike C, Kohn, Kurt W., Weinstein, John N., Munson, Peter J., Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992871/
https://ncbi.nlm.nih.gov/pubmed/20817775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2491
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker