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Transcription poisoning by topoisomerase I is controlled by gene length, splice sites and miR-142-3p
Topoisomerase I (Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and down-stream of transcription complexes. Top1cc can be trapped by carcinogenic and endogenous DNA lesions and by camptothecins resulting in transcription blocks. Here, we undertook genome-wide ana...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3874869/ https://ncbi.nlm.nih.gov/pubmed/23786772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3504 |
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