Transcription poisoning by topoisomerase I is controlled by gene length, splice sites and miR-142-3p

Topoisomerase I (Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and down-stream of transcription complexes. Top1cc can be trapped by carcinogenic and endogenous DNA lesions and by camptothecins resulting in transcription blocks. Here, we undertook genome-wide ana...

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Main Authors: Solier, Stéphanie, Ryan, Michael C., Martin, Scott E., Varma, Sudhir, Kohn, Kurt W., Liu, Hongfang, Zeeberg, Barry R., Pommier, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874869/
https://ncbi.nlm.nih.gov/pubmed/23786772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3504
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