Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design.

The malaria parasite has an obligate calcium requirement for normal intracellular growth and invasion of host erythrocytes. Calmodulin (CaM) is a vital calcium-dependent protein present in eukaryotes. We found by radioimmunoassay that free parasites contain CaM. Schizont-infected erythrocytes had Ca...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Scheibel, L W, Colombani, P M, Hess, A D, Aikawa, M, Atkinson, C T, Milhous, W K
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1987
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3313391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.20.7310
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