Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design.

The malaria parasite has an obligate calcium requirement for normal intracellular growth and invasion of host erythrocytes. Calmodulin (CaM) is a vital calcium-dependent protein present in eukaryotes. We found by radioimmunoassay that free parasites contain CaM. Schizont-infected erythrocytes had Ca...

Full description

Saved in:
Bibliographic Details
Main Authors: Scheibel, L W, Colombani, P M, Hess, A D, Aikawa, M, Atkinson, C T, Milhous, W K
Format: Artigo
Language:Inglês
Published: 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC299282/
https://ncbi.nlm.nih.gov/pubmed/3313391
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items