Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design.
The malaria parasite has an obligate calcium requirement for normal intracellular growth and invasion of host erythrocytes. Calmodulin (CaM) is a vital calcium-dependent protein present in eukaryotes. We found by radioimmunoassay that free parasites contain CaM. Schizont-infected erythrocytes had Ca...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3313391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.20.7310 |
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