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Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.

5-Fluoroorotate is known to have potent antimalarial activity against chloroquine-susceptible as well as chloroquine-resistant clones of Plasmodium falciparum. It was hypothesized that this activity was mediated through synthesis of 5-fluoro-2'-deoxyuridylate, an inactivator of thymidylate synt...

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Sonraí Bibleagrafaíochta
Main Authors: Rathod, P K, Leffers, N P, Young, R D
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1992
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC189360/
https://ncbi.nlm.nih.gov/pubmed/1503432
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