Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.
5-Fluoroorotate is known to have potent antimalarial activity against chloroquine-susceptible as well as chloroquine-resistant clones of Plasmodium falciparum. It was hypothesized that this activity was mediated through synthesis of 5-fluoro-2'-deoxyuridylate, an inactivator of thymidylate synthase,...
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| Опубликовано в:: | Antimicrob Agents Chemother |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
1992
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189360/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1503432/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.4.704 |
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