Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.

5-Fluoroorotate is known to have potent antimalarial activity against chloroquine-susceptible as well as chloroquine-resistant clones of Plasmodium falciparum. It was hypothesized that this activity was mediated through synthesis of 5-fluoro-2'-deoxyuridylate, an inactivator of thymidylate synthase,...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Rathod, P K, Leffers, N P, Young, R D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189360/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1503432/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.4.704
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