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Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor

[Image: see text] Antagonists of the neuropeptide S receptor have been postulated as promising therapeutics in the treatment of respiratory, sleep, anxiety, and addictive disorders. Here, we present the SAR of a new series of orthosteric antagonists. Neuropeptide S receptor signaling is coupled to b...

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מידע ביבליוגרפי
Main Authors: McCoy, Joshua G., Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Huang, Wenwei, Heilig, Markus, Austin, Christopher P.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2010
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992437/
https://ncbi.nlm.nih.gov/pubmed/21116448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100040h
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