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Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format

Cell-based functional assays used for compound screening and lead optimization play an important role in drug discovery for G-protein coupled receptors (GPCRs). Cell-based assays can define the role of a compound as an agonist, antagonist or inverse agonist and can provide detailed information about...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Ke, Titus, Steve, Southall, Noel, Zhu, Pingjun, Inglese, James, Austin, Christopher P, Zheng, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Bentham Open 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774619/
https://ncbi.nlm.nih.gov/pubmed/20161830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397300801010070
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