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Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation

Human prolactin (hPRL), a member of the family of hematopoietic cytokines, functions as both an endocrine hormone and autocrine/paracrine growth factor. We have previously demonstrated that recognition of the hPRL·receptor depends strongly on solution acidity over the physiologic range from pH 6 to...

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Autori principali: Kulkarni, Mandar V., Tettamanzi, M. Cristina, Murphy, James W., Keeler, Camille, Myszka, David G., Chayen, Naomi E., Lolis, Elias J., Hodsdon, Michael E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992285/
https://ncbi.nlm.nih.gov/pubmed/20889499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172072
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