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In silico investigation of pH-dependence of prolactin and human growth hormone binding to human prolactin receptor

Experimental data shows that the binding of human prolactin (hPRL) to human prolactin receptor (hPRLr-ECD) is strongly pH-dependent, while the binding of the same receptor to human growth hormone (hGH) is pH-independent. Here we carry in silico analysis of the molecular effects causing such a differ...

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Detalhes bibliográficos
Main Authors: Wang, Lin, Witham, Shawn, Zhang, Zhe, Li, Lin, Hodsdon, Michael E., Alexov, Emil
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966486/
https://ncbi.nlm.nih.gov/pubmed/24683423
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