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Full Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and Molecular Dynamics Simulations

During co-translational folding, the nascent polypeptide chain is extruded sequentially from the ribosome exit tunnel and, under severe conformational constraints, is dictated by its one-dimensional geometry. How do such vectorial constraints impact the folding pathway? Here, we combine single-molec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Whasil, Zeng, Xiancheng, Zhou, Huan-Xiang, Bennett, Vann, Yang, Weitao, Marszalek, Piotr E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992250/
https://ncbi.nlm.nih.gov/pubmed/20870713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179697
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