Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

The γ-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (APP), which releases Alzheimer disease β-amyloid peptide. In addition to APP, γ-secretase also cleaves several other type I membrane protein substrates including Notch1 and N-cadherin. γ-Secretase is...

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Xehetasun bibliografikoak
Egile Nagusiak: Gong, Ping, Vetrivel, Kulandaivelu S., Nguyen, Phuong D., Meckler, Xavier, Cheng, Haipeng, Kounnas, Maria Z., Wagner, Steven L., Parent, Angèle T., Thinakaran, Gopal
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992238/
https://ncbi.nlm.nih.gov/pubmed/20921220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132613
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