The Role of cis Dimerization of Signal Regulatory Protein α (SIRPα) in Binding to CD47

Interaction of SIRPα with its ligand, CD47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytokine secretion. Recent progress has provided significant insights into the structural details of the distal IgV domain (D1) of SIRPα. However, the structural ro...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Winston Y., Weber, Dominique A., Laur, Oskar, Stowell, Sean R., McCall, Ingrid, Andargachew, Rakieb, Cummings, Richard D., Parkos, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992229/
https://ncbi.nlm.nih.gov/pubmed/20826801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180018
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