Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

Progressive amyloid deposition in senile plaques and cortical blood vessels may play a central role in the pathogenesis of Alzheimer disease. We have used x-ray diffraction and electron microscopy to study the molecular organization and morphology of macromolecular assemblies formed by three synthet...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kirschner, D A, Inouye, H, Duffy, L K, Sinclair, A, Lind, M, Selkoe, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3477820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.19.6953
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