Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrPSc. A synthetic peptide homologous to residues 106–126 of PrP (PrP106–126) was reported to maintain the neurodegenerative characteristics of PrPSc....

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Bibliografiske detaljer

Principais autores:	Stefano Thellung, Tullio Florio, Valentina Villa, Alessandro Corsaro, Sara Arena, Carolina Amico, Mauro Robello, Mario Salmona, Gianluigi Forloni, Orso Bugiani, Fabrizio Tagliavini, Gennaro Schettini
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2000-08-01
Serier:	Neurobiology of Disease
Fag:	prion protein apoptosis L-type voltage-sensitive calcium channels nicardipine
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0969996100903012
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