Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

Primary malignant gliomas from 63 patients were analyzed to determine the relationship between amplification of the gene encoding the epidermal growth factor receptor (EGFR) and expression of the corresponding mRNA. Twenty-four tumors were found to have amplified the EGFR gene and amplification of o...

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Detalhes bibliográficos
Main Authors: Wong, A J, Bigner, S H, Bigner, D D, Kinzler, K W, Hamilton, S R, Vogelstein, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299192/
https://ncbi.nlm.nih.gov/pubmed/3477813
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