Accurate modification of a chromosomal plasmid by homologous recombination in human cells.

We have examined the consequences of modifying mammalian cellular DNA sequences by homologous recombination. A plasmid carrying a 248-base-pair deletion in the neomycin phosphotransferase (neo) gene was introduced into hamster and human cells. The integrated, defective neo gene was used as a target...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Song, K Y, Schwartz, F, Maeda, N, Smithies, O, Kucherlapati, R
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1987
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299176/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821545/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.19.6820
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