Phenotypic Consequences of Copy Number Variation: Insights from Smith-Magenis and Potocki-Lupski Syndrome Mouse Models

A large fraction of genome variation between individuals is comprised of submicroscopic copy number variation of genomic DNA segments. We assessed the relative contribution of structural changes and gene dosage alterations on phenotypic outcomes with mouse models of Smith-Magenis and Potocki-Lupski...

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Detalhes bibliográficos
Main Authors: Ricard, Guénola, Molina, Jessica, Chrast, Jacqueline, Gu, Wenli, Gheldof, Nele, Pradervand, Sylvain, Schütz, Frédéric, Young, Juan I., Lupski, James R., Reymond, Alexandre, Walz, Katherina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990707/
https://ncbi.nlm.nih.gov/pubmed/21124890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000543
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