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Opposing phenotypes in mice with Smith-Magenis deletion and Potocki -Lupski duplication syndromes suggest gene dosage effects on fluid consumption behavior

A quantitative long-term fluid consumption and fluid licking assay was performed in two mouse models with either an ~ 2Mb genomic deletion, Df(11)17, or the reciprocal duplication CNV, Dp(11)17, analogous to the human genomic rearrangements causing either Smith-Magenis syndrome [SMS; OMIM #182290] o...

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Bibliografiske detaljer
Main Authors: Heck, Detlef H., Gu, Wenli, Cao, Ying, Qi, Shuhua, Lacaria, Melanie, Lupski, James R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477298/
https://ncbi.nlm.nih.gov/pubmed/22991245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.35601
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