Enhanced Induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic Cell-targeted Delivery of SOCS-1 siRNA

Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in the activation of T cells. RNA interference (RNAi)-mediated silencing of negative immunoregulatory molecules expressed by DCs may provide a strategy to enhance the potency of DC-based vaccines and immunotherapy. A...

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Main Authors: Subramanya, Sandesh, Armant, Myriam, Salkowitz, Janelle R, Nyakeriga, Alice M, Haridas, Viraga, Hasan, Maroof, Bansal, Anju, Goepfert, Paul A, Wynn, Katherine K, Ladell, Kristin, Price, David A, N, Manjunath, Kan-Mitchell, June, Shankar, Premlata
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990509/
https://ncbi.nlm.nih.gov/pubmed/20648001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.148
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