Nalaganje...

Complete deletion of Apc results in severe polyposis in mice

The adenomatous polyposis coli (APC) gene product is mutated in the vast majority of human colorectal cancer. APC negatively regulates the WNT pathway by aiding in the degradation of β-Catenin, the transcription factor activated downstream of WNT signaling. APC mutations result in β-Catenin stabiliz...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Cheung, Ann F., Carter, Alia M., Kostova, Kamena K., Woodruff, Joseph F., Crowley, Denise, Bronson, Roderick T., Haigis, Kevin M., Jacks, Tyler
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990498/
https://ncbi.nlm.nih.gov/pubmed/20010873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.457
Oznake: Označite
Brez oznak, prvi označite!