Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model

We previously demonstrated that mesenchymal stem/stromal cells (MSC) are recruited to tumors and that IFN-β produced by MSC inhibited tumor growth in xenograft models. Because of a deficient immune system, murine xenograft models cannot fully recapitulate tumor and immune cell interactions during pr...

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Detalhes bibliográficos
Main Authors: Ling, Xiaoyang, Marini, Frank, Konopleva, Marina, Schober, Wendy, Shi, Yuexi, Burks, Jared, Clise-Dwyer, Karen, Wang, Rui-Yu, Zhang, Weiguo, Yuan, Xiaoqing, Lu, Hongbo, Caldwell, Lisa, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2010
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990497/
https://ncbi.nlm.nih.gov/pubmed/21209776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12307-010-0041-8
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