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Long range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance

The fidelity of the poliovirus RNA-dependent RNA polymerase (3D(pol)) plays a direct role in the genomic evolution and pathogenesis of the virus. A single site mutation (Gly64Ser) that is remote from the catalytic center results in a higher fidelity polymerase. NMR studies with [methyl-(13)C]methion...

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Autors principals: Yang, Xiaorong, Welch, Jesse L., Arnold, Jamie J., Boehr, David D.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989882/
https://ncbi.nlm.nih.gov/pubmed/20860410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100833r
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