Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

Gain of chromosome 8 is the most common chromosomal gain in human acute myeloid leukemia (AML). It has been hypothesized that gain of the MYC protooncogene is of central importance in trisomy 8, but the experimental data to support this are limited and controversial. In a mouse model of promyelocyti...

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Detalhes bibliográficos
Main Authors: Jones, Letetia, Wei, Guangwei, Sevcikova, Sabina, Phan, Vernon, Jain, Sachi, Shieh, Angell, Wong, Jasmine C. Y., Li, Min, Dubansky, Joshua, Maunakea, Mei Lin, Ochoa, Rachel, Zhu, George, Tennant, Thelma R., Shannon, Kevin M., Lowe, Scott W., Le Beau, Michelle M., Kogan, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989761/
https://ncbi.nlm.nih.gov/pubmed/21059853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091071
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