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The Development of Recurrent Seizures after Continuous Intrahippocampal Infusion of Methionine Sulfoximine in Rats: A Video-Intracranial Electroencephalographic Study

Glutamine synthetase is deficient in astrocytes in the epileptogenic hippocampus in human mesial temporal lobe epilepsy (MTLE). To explore the role of this deficiency in the pathophysiology of MTLE, rats were continuously infused with the glutamine synthetase inhibitor methionine sulfoximine (MSO, 0...

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Autors principals: Wang, Yue, Zaveri, Hitten P., Lee, Tih-Shih W, Eid, Tore
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989153/
https://ncbi.nlm.nih.gov/pubmed/19747915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.08.034
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