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The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

The death inducing signaling complex (DISC) formed by the death receptor Fas, the adapter protein FADD and caspase-8 mediates the extrinsic apoptotic program. Mutations in Fas that disrupt the DISC cause autoimmune lymphoproliferative syndrome (ALPS). Here we show that the Fas–FADD death domain (DD)...

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Dettagli Bibliografici
Autori principali: Wang, Liwei, Yang, Jin Kuk, Kabaleeswaran, Venkataraman, Rice, Amanda J., Cruz, Anthony C., Park, Ah Young, Yin, Qian, Damko, Ermelinda, Jang, Se Bok, Raunser, Stefan, Robinson, Carol V., Siegel, Richard M., Walz, Thomas, Wu, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988912/
https://ncbi.nlm.nih.gov/pubmed/20935634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1920
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