The Preferred Substrates for Transglutaminase 2 in a Complex Wheat Gluten Digest Are Peptide Fragments Harboring Celiac Disease T-Cell Epitopes

BACKGROUND: Celiac disease is a T-cell mediated chronic inflammatory disorder of the gut that is induced by dietary exposure to gluten proteins. CD4+ T cells of the intestinal lesion recognize gluten peptides in the context of HLA-DQ2.5 or HLA-DQ8 and the gluten derived peptides become better T-cell...

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Main Authors: Dørum, Siri, Arntzen, Magnus Ø., Qiao, Shuo-Wang, Holm, Anders, Koehler, Christian J., Thiede, Bernd, Sollid, Ludvig M., Fleckenstein, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988817/
https://ncbi.nlm.nih.gov/pubmed/21124911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014056
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