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BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells

BK channels are large unitary conductance K(+) channels cooperatively activated by intracellular calcium and membrane depolarisation. We show that BK channels regulate electrical activity in β-cells of mouse pancreatic islets exposed to elevated glucose. In 11.1 mm glucose, the non-peptidyl BK chann...

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Detalhes bibliográficos
Main Authors: Houamed, Khaled M, Sweet, Ian R, Satin, Leslie S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988515/
https://ncbi.nlm.nih.gov/pubmed/20643769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.184341
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