The Novel PMCA2 Pump Mutation Tommy Impairs Cytosolic Calcium Clearance in Hair Cells and Links to Deafness in Mice

The mechanotransduction process in hair cells in the inner ear is associated with the influx of calcium from the endolymph. Calcium is exported back to the endolymph via the splice variant w/a of the PMCA2 of the stereocilia membrane. To further investigate the role of the pump, we have identified a...

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Detalhes bibliográficos
Main Authors: Bortolozzi, Mario, Brini, Marisa, Parkinson, Nick, Crispino, Giulia, Scimemi, Pietro, De Siati, Romolo Daniele, Di Leva, Francesca, Parker, Andrew, Ortolano, Saida, Arslan, Edoardo, Brown, Steve D., Carafoli, Ernesto, Mammano, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988374/
https://ncbi.nlm.nih.gov/pubmed/20826782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170092
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