The Novel PMCA2 Pump Mutation Tommy Impairs Cytosolic Calcium Clearance in Hair Cells and Links to Deafness in Mice

The mechanotransduction process in hair cells in the inner ear is associated with the influx of calcium from the endolymph. Calcium is exported back to the endolymph via the splice variant w/a of the PMCA2 of the stereocilia membrane. To further investigate the role of the pump, we have identified a...

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Main Authors: Bortolozzi, Mario, Brini, Marisa, Parkinson, Nick, Crispino, Giulia, Scimemi, Pietro, De Siati, Romolo Daniele, Di Leva, Francesca, Parker, Andrew, Ortolano, Saida, Arslan, Edoardo, Brown, Steve D., Carafoli, Ernesto, Mammano, Fabio
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988374/
https://ncbi.nlm.nih.gov/pubmed/20826782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170092
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