A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness

Ca(2+) enters the stereocilia of hair cells through mechanoelectrical transduction channels opened by the deflection of the hair bundle and is exported back to endolymph by an unusual splicing isoform (w/a) of plasma-membrane calcium-pump isoform 2 (PMCA2). Ablation or missense mutations of the pump...

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Autors principals: Ficarella, R., Di Leva, F., Bortolozzi, M., Ortolano, S., Donaudy, F., Petrillo, M., Melchionda, S., Lelli, A., Domi, T., Fedrizzi, L., Lim, D., Shull, G. E., Gasparini, P., Brini, M., Mammano, F., Carafoli, E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785272/
https://ncbi.nlm.nih.gov/pubmed/17234811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609775104
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