AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

Diabetes and high glucose (HG) increase the generation of NADPH oxidase-derived reactive oxygen species and induce apoptosis of glomerular epithelial cells (podocytes). Loss of podocytes contributes to albuminuria, a major risk factor for progression of kidney disease. Here, we show that HG inactiva...

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Bibliographic Details
Main Authors: Eid, Assaad A., Ford, Bridget M., Block, Karen, Kasinath, Balakuntalam S., Gorin, Yves, Ghosh-Choudhury, Goutam, Barnes, Jeffrey L., Abboud, Hanna E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988355/
https://ncbi.nlm.nih.gov/pubmed/20861022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136796
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