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Synthetic Utility of Epoxides for Chiral Functionalization of Isoxazoles
The lithio-anion of isoxazole 2 was found to ring open propylene oxide in good yields with complete regioselectivity. Vinylic and benzylic epoxides were utilized as key examples of electrophiles and found to produce a mixture of regioisomeric adducts. Additionally, the use of chiral epoxides was exp...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988249/ https://ncbi.nlm.nih.gov/pubmed/21103024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2008.03.059 |
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