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Lentiviral shRNA knockdown of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture
Aggrecan is one of the two major constituents of articular cartilage, and during diseases such as osteoarthritis (OA) it is subject to degradation by proteolytic enzymes. The primary proteases responsible for aggrecan cleavage are the aggrecanases, identified as members of the ADAMTS family of prote...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988096/ https://ncbi.nlm.nih.gov/pubmed/20568084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/term.275 |
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