Structural basis of HIV-1 resistance to AZT by excision

Human immunodeficiency virus (HIV-1) develops resistance to 3′-azido-2′,3′-deoxythymidine (AZT, zidovudine) by acquiring mutations in reverse transcriptase that enhance the ATP-mediated excision of AZT monophosphate from the 3′ end of the primer. The excision reaction occurs at the dNTP-binding site...

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Autori principali: Tu, Xiongying, Das, Kalyan, Han, Qianwei, Bauman, Joseph D, Clark, Arthur D, Hou, Xiaorong, Frenkel, Yulia V, Gaffney, Barbara L, Jones, Roger A, Boyer, Paul L, Hughes, Stephen H, Sarafianos, Stefan G, Arnold, Eddy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987654/
https://ncbi.nlm.nih.gov/pubmed/20852643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1908
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