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Understanding missense mutations in the BRCA1 gene: An evolutionary approach
The role of missense changes in BRCA1 in breast cancer susceptibility has been difficult to establish. We used comparative evolutionary methods to identify potential functionally important amino acid sites in exon 11 and missense changes likely to disrupt gene function, aligning sequences from 57 eu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298742/ https://ncbi.nlm.nih.gov/pubmed/12531920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237285100 |
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