A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.

Inherited susceptibility to ovarian cancer has been associated with germline defects at several loci. The major known ovarian cancer susceptibility gene is BRCA1 on chromosome 17q, which confers a risk of approximately 60% by the age of 70 years. Truncating mutations in BRCA2 on chromosome 13q also...

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Detalhes bibliográficos
Main Authors: Roth, S., Kristo, P., Auranen, A., Shayehgi, M., Seal, S., Collins, N., Barfoot, R., Rahman, N., Klemi, P. J., Grénman, S., Sarantaus, L., Nevanlinna, H., Butzow, R., Ashworth, A., Stratton, M. R., Aaltonen, L. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150153/
https://ncbi.nlm.nih.gov/pubmed/9579822
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