Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stab...

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Main Authors: Leung, K. C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C. K. W., Low, T. H., Leong, G. M., Ross, R. J. M., Ho, K. K. Y.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2003
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC298718/
https://ncbi.nlm.nih.gov/pubmed/12552091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337600100
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