SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 ty...

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Библиографические подробности
Главные авторы: Elliott, Joanne, Suessmuth, Yvonne, Scott, Linda M., Nahlik, Krystyna, McMullin, Mary Frances, Constantinescu, Stefan N., Green, Anthony R., Johnston, James A.
Формат: Artigo
Язык:Inglês
Опубликовано: Ferrata Storti Foundation 2009
Предметы:
Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663621/
https://ncbi.nlm.nih.gov/pubmed/19229050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.002352
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