SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases

JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 ty...

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Main Authors: Elliott, Joanne, Suessmuth, Yvonne, Scott, Linda M., Nahlik, Krystyna, McMullin, Mary Frances, Constantinescu, Stefan N., Green, Anthony R., Johnston, James A.
格式: Artigo
語言:Inglês
出版: Ferrata Storti Foundation 2009
主題:
Brief Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663621/
https://ncbi.nlm.nih.gov/pubmed/19229050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.002352
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