Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stab...

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Hlavní autoři: Leung, K. C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C. K. W., Low, T. H., Leong, G. M., Ross, R. J. M., Ho, K. K. Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC298718/
https://ncbi.nlm.nih.gov/pubmed/12552091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337600100
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