Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain

Thiopurine S-methyltransferase (TPMT) is the rate-limiting step in the conversion of thiopurine drugs including azathioprine (AZA) to inactive metabolites. Heritable deficiency of TPMT activity increases risk for adverse events, most notably, myelosuppression leading to leukopenia and neutropenic se...

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Main Authors: Gurwitz, David, Rodríguez-Antona, Cristina, Payne, Katherine, Newman, William, Gisbert, Javier P, de Mesa, Emma Gutiérrez, Ibarreta, Dolores
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2986553/
https://ncbi.nlm.nih.gov/pubmed/19223932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2009.10
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