Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population

1. Characterization of allelic variants of the TPMT gene (TPMT) responsible for changes in TPMT activity, and elucidation of the mechanism by which these alleles act, are required because of the clinical importance of this polymorphism for patients receiving thiopurine drugs. 2. We defined the mutat...

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Autori principali: Spire-Vayron de la Moureyre, Catherine, Debuysere, Hervé, Mastain, Bruno, Vinner, Elizabeth, Marez, Delphine, Lo Guidice, Jean-Marc, Chevalier, Dany, Brique, Serge, Motte, Kokou, Colombel, Jean-Frédéric, Turck, Dominique, Noel, Christian, Flipo, René-Marc, Pol, Annie, Lhermitte, Michel, Lafitte, Jean-Jacques, Libersa, Christian, Broly, Franck
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571045/
https://ncbi.nlm.nih.gov/pubmed/9831928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702152
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